Domanico, Paul L.: search on Z-Library

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1

Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro

Caperelli, Carol A., Domanico, Paul, Benkovic, Stephen J.

Journal:

Journal of Medicinal Chemistry

Year:

1981

Language:

english

File:

PDF, 452 KB

english, 1981

2

Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of methyl (R,R)-(.+-.)-3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.

Stafford, Jeffrey A., Veal, James M., Feldman, Paul L., Valvano, Nicole L., Baer, Philip G., Brackeen, Marcus F., Brawley, E. Sloan, Connolly, Kevin M., Domanico, Paul L.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.36 MB

english, 1995

3

Cleavage of dT8 and dT8 phosphorothioyl analogues by Escherichia coli DNA topoisomerase I: product and rate analysis

Domanico, Paul L., Tse-Dinh, Yuk Ching

Journal:

Year:

1988

Language:

english

File:

PDF, 943 KB

english, 1988

4

Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species

Dix, Thomas A., Bollag, Gideon E., Domanico, Paul, Benkovic, Stephen J.

Journal:

Year:

1985

Language:

english

File:

PDF, 453 KB

english, 1985

5

Adenosine 5'-O-(3-thiotriphosphate) hydrolysis by dynein

Shimizu, Takashi, Katsura, Tatsuo, Domanico, Paul L., Marchese-Ragona, Silvio P., Johnson, Kenneth A.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.16 MB

english, 1989

6

Structure-activity relationships involving the catechol subunit of rolipram

Jeffrey A. Stafford, Paul L. Feldman, Brian E. Marron, Frank J. Schoenen, Nicole L. Valvano, Rayomand J. Unwalla, Paul L. Domanico, E.Sloan Brawley, Michael A. Leesnitzer, Dudley A. Rose, Robert W. Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 475 KB

english, 1994

7

Dual Inhibition of Human Type 4 Phosphodiesterase Isostates by ( R , R )-(±)-Methyl 3-Acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate

Tian, Gaochao, Rocque, Warren J., Wiseman, Jeffrey S., Thompson, Irene Z., Holmes, William D., Domanico, Paul L., Stafford, Jeffrey A., Feldman, Paul L., Luther, Michael A.

Journal:

Year:

1998

Language:

english

File:

PDF, 140 KB

english, 1998

8

17.beta.-(N-tert-Butylcarbamoyl)-4-aza-5.alpha.-androstan-1-en-3-one Is an Active Site-Directed Slow Time-Dependent Inhibitor of Human Steroid 5.alpha.-Reductase 1

Tian, Gaochao, Stuart, J. Darren, Moss, Marcia L., Domanico, Paul L., Bramson, H. Neal, Patel, Indravadan R., Kadwell, Sue H., Overton, Laurie K., Kost, Thomas A.

Journal:

Year:

1994

Language:

english

File:

PDF, 688 KB

english, 1994

9

In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)

Zlotnick, Adam, Lee, Angela, Bourne, Christina R, Johnson, Jennifer M, Domanico, Paul L, Stray, Stephen J

Journal:

Bioentrepreneur

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

10

Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: kinetics and mechanisms

Besterman, Jeffrey M., Domanico, Paul L.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.09 MB

english, 1992

11

Phosphodiesterase Type IV Inhibition. Structure-Activity Relationships of 1,3-Disubstituted Pyrrolidines

Feldman, Paul L., Brackeen, Marcus F., Cowan, David J., Marron, Brian E., Schoenen, Frank J., Stafford, Jeffrey A., Suh, Edward M., Domanico, Paul L., Rose, Dudley

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 724 KB

english, 1995

12

The transition to dolutegravir and other new antiretrovirals in low- and middle-income countries – what are the issues?

Vitoria, Marco, Hill, Andrew, Ford, Nathan, Doherty, Meg, Clayden, Polly, Venter, Francois, Ripin, David, Flexner, Charles, Domanico, Paul

Journal:

Year:

2018

Language:

english

File:

PDF, 285 KB

english, 2018

13

Mechanistic studies on E. coli DNA topoisomerase I: Divalent ion effects

Paul L. Domanico, Yuk Ching Tse-Dinh

Journal:

Journal of Inorganic Biochemistry

Year:

1991

Language:

english

File:

PDF, 841 KB

english, 1991

14

On the mechanism of action of phenylalanine hydroxylase

BENKOVIC, STEPHEN, WALLICK, DAVID, BLOOM, LESLIE, GAFFNEY, BETTY JEAN, DOMANICO, PAUL, DIX, THOMAS, PEMBER, STEPHEN

Journal:

Biochemical Society Transactions

Year:

1985

Language:

english

File:

PDF, 315 KB

english, 1985

15

Phosphodiesterase type IV (PDE IV) inhibition. Synthesis and evaluation of a series of 1,3,4-trisubstituted pyrrolidines

Jeffrey A Stafford, Nicole L Valvano, Paul L Feldman, E Sloan Brawley, David J Cowan, Paul L Domanico, Michael A Leesnitzer, Dudley A Rose, Stephen A Stimpson, Alan B Strickland, Rayomand J Unwalla, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 302 KB

english, 1995

16

Experimental design for high-throughput screening

Michael W. Lutz, J. Alan Menius, Tony D. Choi, Rebecca Gooding Laskody, Paul L. Domanico, Aaron S. Goetz, David L. Saussy

Journal:

Drug Discovery Today

Year:

1996

Language:

english

File:

PDF, 1.12 MB

english, 1996

17

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

Moss, Darren M., Domanico, Paul, Watkins, Melynda, Park, Seonghee, Randolph, Ryan, Wring, Steve, Rajoli, Rajith Kumar Reddy, Hobson, James, Rannard, Steve, Siccardi, Marco, Owen, Andrew

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 728 KB

english, 2017

18

Design and Synthesis of Conformationally Constrained Analogs of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase

Brackeen, Marcus F., Stafford, Jeffrey A., Cowan, David J., Brown, Peter J., Domanico, Paul L., Feldman, Paul L., Rose, Dudley, Strickland, Alan B., Veal, James M., Verghese, Margrith

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.25 MB

english, 1995

19

Unambiguous stereochemical course of rabbit liver fructose bisphosphatase hydrolysis

Domanico, Paul L., Rahil, Jubrail F., Benkovic, Stephen J.

Journal:

Year:

1985

Language:

english

File:

PDF, 778 KB

english, 1985

20

Discovery research: innovation and automation

Paul L. Domanico

Journal:

Chemometrics and Intelligent Laboratory Systems

Year:

1994

Language:

english

File:

PDF, 703 KB

english, 1994

21

Pharmacologists get a bigger and better tool box

Terry Kenakin, Paul Domanico

Journal:

Current Opinion in Pharmacology

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

22

Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

Watkins, Melynda E., Wring, Steve, Randolph, Ryan, Park, Seonghee, Powell, Kendall, Lutz, Lissa, Nowakowski, Michelle, Ramabhadran, Ram, Domanico, Paul L.

Journal:

Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 3.06 MB

english, 2017

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